Astronomers Catch Video of 'Near-Miss' Asteroid

Image: R. P. Binzel, M. Lockhart (MIT); B. Golisch, S. J. Bus, T. Denault, J. Rayner, A. Tokunaga (NASA IRTF); A. Gulbis (SALT)

From Nature magazine

A small asteroid called 2012 KT₄₂ came within three Earth radii of striking the planet on 29 May, but slipped past. The event was the sixth-closest encounter of any recorded asteroid.

In a video posted online on 19 June by researchers using NASA's Infrared Telescope Facility (IRTF) in Hawaii, the bright asteroid appears fixed, while background stars zip past (in fact, the asteroid is speeding along at 17 kilometres per second). ?You get the view of riding along with it,? says Richard Binzel, a planetary scientist at the Massachusetts Institute of Technology in Cambridge, who led the observations. At its closest, the asteroid was around 19,000 kilometres from Earth ? a distance between the orbit of the International Space Station (about 1 Earth radius) and that of a geosynchronous satellite (about 6 Earth radii).

Hours after the object was discovered by a small telescope on Mount Lemmon near Tucson, Arizona, Binzel was able to obtain a few hours of time on the IRTF. The resulting in-depth study was innovative for such a small object.

By determining 2012 KT₄₂'s composition and reflectivity, Binzel was able to use the brightness of the asteroid to estimate its size: about 7 metres across. He says several objects this size cross Earth?s path every year.

?

2012 KT₄₂ is now continuing on its 1.5-year elliptical orbit of the Sun. Even if it had struck Earth, Binzel says, it probably would have burned up in the atmosphere. Binzel wants to discover an object that is not big enough to present a hazard to Earth, but is large enough to be spotted in space and later found on the ground as a meteorite, as was the asteroid 2008 TC₃, which came to Earth in Sudan in October 2008 (see the 'The rock that fell to Earth'). ?I want them to be just the right size to deliver some fresh samples,? he says.

This article is reproduced with permission from the magazine Nature. The article was first published on June 21, 2012.

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Research shows new prognosis tool for deadly brain cancer

A diagnosis of glioblastoma multiforme (GBM) is generally a death sentence, but new research from the University of Wisconsin-Madison lab of Dr. John Kuo shows that at least one subtype is associated with a longer life expectancy. This discovery could help with better patient prognoses and lead to targeted drug treatments for GBM subtypes.

People diagnosed with GBM live on average less than 15 months after diagnosis, even after undergoing aggressive surgery, radiation and chemotherapy. But not all GBM cancers are the same, and Kuo's study outlines a new method for sub-typing GBM tumor lines by the proteins they express.

The paper, published early online by the journal Clinical Cancer Research, shows that people who have a subtype of GBM that expresses a particular protein, known for short as CNP, may have a less aggressive subtype of cancer. The survival rate for those with the subtype is sometimes measured in years, not months.

The group isolated tumor lines from five human patients and grew them in the lab, and then looked for biomarkers specific to each line. They later transplanted the tissue into the brains of mice with compromised immune systems.

The researchers also looked for the CNP subtype in samples from 115 human patients and then looked at data on survival rates for those patients. They found that some patients with the protein lived much longer, as long as 10 years after diagnosis.

"We found that this protein was correlated with a less invasive type of cancer in mice, and when we looked at samples of human tumors, remarkably, we also found that the less invasive tumors expressed the CNP protein,'' says Kuo, assistant professor of neurological surgery and human oncology at UW School of Medicine and Public Health.

Kuo says the sub-typing could lead to more accurate prognosis for patients with a GBM diagnosis. Currently, most sub-typing of GBM tumors is based on mRNA, which can be difficult to do. But Kuo says that most hospitals can run assays for proteins, making the test simpler and easier.

In addition, says Michael Zorniak, Kuo's graduate student and lead author on the paper, the new way of typing tumors could lead to designer chemotherapy for GBM.

"As we understand how tumors are differentiated, we can start devising personalized therapies that are targeted to the specific sub-type of cancer,'' he says. "This can help us gain leverage against this difficult cancer."

For example, researchers could create monoclonal antibodies that bind only to the CNP type of cancer, in the way that some subtypes of breast cancer are currently targeted.

More information: The research will be published in the July issue of Clinical Cancer Research, a journal of the American Association for Cancer Research, and is available on-line here: http://clincancerr ? .CCR-12-0339

Journal reference: Clinical Cancer Research

Provided by University of Wisconsin-Madison

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RealTime Fantasy Sports - Fantasy Football Draft Guide

Tampa Bay Buccaneers RB LeGarrette Blount has been getting the majority of the carries with the first-team offense during organized team activities and minicamp. RB Doug Martin has received [ More ]

Tennessee Titans WR Kendall Wright (shoulder) suffered a shoulder injury during practice Thursday, June 14. He underwent an x-ray on the shoulder but it did not show any structural [ More ]

The Chicago Bears have waived QB Nathan Enderle.

New York Giants offensive coordinator Kevin Gilbride said he has been impressed with how RB David Wilson has done this offseason but said Wilson will need more time to [ More ]

New York Giants head coach Tom Coughlin said WR Rueben Randle has some things to work on but was impressed with how he performed during minicamp. 'Randle's demonstrated not [ More ]

The Houston Texans have signed free-agent FB Moran Norris (49ers). Terms of the contract were not disclosed.

The St. Louis Rams have signed free-agent LB Rocky McIntosh (Redskins). Terms of the contract were not disclosed.

New York Jets QB Tim Tebow received some snaps with the first-team offense during practice Thursday, June 14. Head coach Rex Ryan said offensive coordinator Tony Sparano wanted to [ More ]

Carolina Panthers WR David Gettis (knee) said he has been taking the rehab from his torn anterior cruciate ligament slowly this offseason because he wants to be careful with [ More ]

Carolina Panthers LB Thomas Davis (knee) said he expects to be ready to participate once training camp begins. He said he could have participated in minicamp but the team is being cautious with him.

Carolina Panthers LB Jon Beason (Achilles') has been participating in team drills during minicamp this week. It appears Beason has been running close to full speed during practice.

Cleveland Browns president Mike Holmgren said the plan at this point is to keep QBs Colt McCoy and Seneca Wallace on the roster but indicated that the team may [ More ]

Dallas Cowboys second-year RB DeMarco Murray might play a larger role in the passing game this season. He has caught a lot of passes during summer workouts.

Indianapolis Colts RB Delone Carter (thumb) said he is about 80-85 percent healthy, but he plans to be ready for the start of training camp in late July. [ More ]

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Former NFL LB Tedy Bruschi said New York Jets QB Tim Tebow should just disappear and not talk so much to the media. In response, Tebow said he [ More ]

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Obesity negatively predicts minimal disease activity achievement in patients with PSA

Public release date: 8-Jun-2012
[ | E-mail | Share ]

Contact: Candice Debleu
eularpressoffice@cohnwolfe.com
44-789-438-6425
European League Against Rheumatism

Following a hypocaloric diet increases the chance of achieving minimal disease activity

Berlin, Germany, June 8 2012: According to a study presented today at EULAR 2012, the Annual Congress of the European League Against Rheumatism, patients with psoriatic arthritis (PsA) who are starting anti-tumour necrosis factor (anti-TNF) treatment and adhere to a hypocaloric diet have a significantly greater chance of achieving minimal disease activity (MDA, an important measure of disease activity) at six months compared to those on a standard diet.

The results of an Italian study of 138 obese PsA patients demonstrated that those who achieved a ?10% weight loss following a calorie restricted diet, were more likely to achieve MDA, compared to patients on a standard diet (p=0.001). These patients also had significantly higher changes in erythrocyte sedimentation rate (ESR, a test that indirectly measures the amount of inflammation in the body), and c-reactive protein (CRP, a marker of systemic inflammation, a recently identified predictor of structural damage progression) compared to patients on a standard diet.

"A study presented at the 2009 meeting of the Society for Investigative Dermatology, alerted us to the fact that patients with psoriatic arthritis have an increased prevalence of obesity, however our study has gone beyond that, assessing whether diet is able to improve the achievement of minimal disease activity in obese patients treated with anti-TNFs" said Dr. Dario Di Minno from the University of Naples Federico II, Italy and lead author of the study. "The results of our study suggest that obese patients with psoriatic arthritis who stick to a hypocaloric diet have a greater chance of achieving treatment goals."

The study demonstrated that a hypocaloric diet is a predictor of MDA achievement (hazard ratio [HR]: 4.79; p=0.002) after six months of treatment with anti-TNFs in patients as compared to those on a standard diet. Of the 138 obese subjects with PsA, 69 received a hypocaloric diet and 69 a self-managed diet. At baseline and at six months follow-up, patients underwent a complete clinical rheumatologic and laboratory evaluation.

In a separate PsA study by the same authors, 135 obese and 135 matched normal-weighted patients (controls) with active disease starting treatment with anti-TNFs were followed for 24 months to evaluate whether the presence of obesity impacts the achievement of MDA. Of the 270 subjects, 36.3% achieved MDA and the prevalence of obesity was higher in those not achieving MDA than in those achieving it (64.0% versus 25.5%, p

###

Abstract Numbers: OP0162, OP0163

NOTES TO EDITORS:

For further information on this study, or to request an interview with the study lead, please do not hesitate to contact the EULAR congress Press Office in Hall 6 on the 3rd floor of the Congress Centre during EULAR 2012 or on:

Email: eularpressoffice@cohnwolfe.com

Candice Debleu:
Onsite tel: +44 7894 386 425

About EULAR

• The European League Against Rheumatism (EULAR) is the organisation which represents the patient, health professional and scientific societies of rheumatology of all the European nations
• In line with The European Union of Medical Specialists (UEMS), EULAR defines rheumatology as including rheumatic diseases of the connective tissue, locomotor and musculoskeletal systems
• EULAR aims to promote, stimulate and support the research, prevention, treatment and rehabilitation of rheumatic diseases. With 45 scientific member societies, 36 PARE organisations and 10 health professionals associations, EULAR underscores the importance of combating rheumatic diseases not only by medical means, but also through a wider context of care for rheumatic patients and a thorough understanding of their social and other needs
• Diseases of the bone and joints such as rheumatoid arthritis and osteoarthritis cause disability in 4-5% of the adult population and are predicted to rise as people live longer
• EULAR 2012 is set to be the biggest rheumatology event in Europe with over 15,000 scientists, physicians, allied health professionals, and related audiences in attendance from over 115 countries. Over the course of the congress, more than 275 oral and 1400 poster abstract presentations will be featured, with 1,010 invited speaker lectures taking place in 190 sessions
• To find out more about the activities of EULAR, visit: www.eular.org

---

[ | E-mail | Share ]

?

AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.

Public release date: 8-Jun-2012
[ | E-mail | Share ]

Contact: Candice Debleu
eularpressoffice@cohnwolfe.com
44-789-438-6425
European League Against Rheumatism

Following a hypocaloric diet increases the chance of achieving minimal disease activity

Berlin, Germany, June 8 2012: According to a study presented today at EULAR 2012, the Annual Congress of the European League Against Rheumatism, patients with psoriatic arthritis (PsA) who are starting anti-tumour necrosis factor (anti-TNF) treatment and adhere to a hypocaloric diet have a significantly greater chance of achieving minimal disease activity (MDA, an important measure of disease activity) at six months compared to those on a standard diet.

The results of an Italian study of 138 obese PsA patients demonstrated that those who achieved a ?10% weight loss following a calorie restricted diet, were more likely to achieve MDA, compared to patients on a standard diet (p=0.001). These patients also had significantly higher changes in erythrocyte sedimentation rate (ESR, a test that indirectly measures the amount of inflammation in the body), and c-reactive protein (CRP, a marker of systemic inflammation, a recently identified predictor of structural damage progression) compared to patients on a standard diet.

"A study presented at the 2009 meeting of the Society for Investigative Dermatology, alerted us to the fact that patients with psoriatic arthritis have an increased prevalence of obesity, however our study has gone beyond that, assessing whether diet is able to improve the achievement of minimal disease activity in obese patients treated with anti-TNFs" said Dr. Dario Di Minno from the University of Naples Federico II, Italy and lead author of the study. "The results of our study suggest that obese patients with psoriatic arthritis who stick to a hypocaloric diet have a greater chance of achieving treatment goals."

The study demonstrated that a hypocaloric diet is a predictor of MDA achievement (hazard ratio [HR]: 4.79; p=0.002) after six months of treatment with anti-TNFs in patients as compared to those on a standard diet. Of the 138 obese subjects with PsA, 69 received a hypocaloric diet and 69 a self-managed diet. At baseline and at six months follow-up, patients underwent a complete clinical rheumatologic and laboratory evaluation.

In a separate PsA study by the same authors, 135 obese and 135 matched normal-weighted patients (controls) with active disease starting treatment with anti-TNFs were followed for 24 months to evaluate whether the presence of obesity impacts the achievement of MDA. Of the 270 subjects, 36.3% achieved MDA and the prevalence of obesity was higher in those not achieving MDA than in those achieving it (64.0% versus 25.5%, p

###

Abstract Numbers: OP0162, OP0163

NOTES TO EDITORS:

For further information on this study, or to request an interview with the study lead, please do not hesitate to contact the EULAR congress Press Office in Hall 6 on the 3rd floor of the Congress Centre during EULAR 2012 or on:

Email: eularpressoffice@cohnwolfe.com

Candice Debleu:
Onsite tel: +44 7894 386 425

About EULAR

• The European League Against Rheumatism (EULAR) is the organisation which represents the patient, health professional and scientific societies of rheumatology of all the European nations
• In line with The European Union of Medical Specialists (UEMS), EULAR defines rheumatology as including rheumatic diseases of the connective tissue, locomotor and musculoskeletal systems
• EULAR aims to promote, stimulate and support the research, prevention, treatment and rehabilitation of rheumatic diseases. With 45 scientific member societies, 36 PARE organisations and 10 health professionals associations, EULAR underscores the importance of combating rheumatic diseases not only by medical means, but also through a wider context of care for rheumatic patients and a thorough understanding of their social and other needs
• Diseases of the bone and joints such as rheumatoid arthritis and osteoarthritis cause disability in 4-5% of the adult population and are predicted to rise as people live longer
• EULAR 2012 is set to be the biggest rheumatology event in Europe with over 15,000 scientists, physicians, allied health professionals, and related audiences in attendance from over 115 countries. Over the course of the congress, more than 275 oral and 1400 poster abstract presentations will be featured, with 1,010 invited speaker lectures taking place in 190 sessions
• To find out more about the activities of EULAR, visit: www.eular.org

---

[ | E-mail | Share ]

?

AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.

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Virgin Mobile To Launch Prepaid iPhone 4 And 4S On June 29

Today, Virgin Mobile has finally put months of rumors and speculation to rest -- starting on June 29, the pre-paid Sprint subsidiary will start selling Apple's iPhone 4 and 4S. Virgin customers can expect to shell out $549 for a non-contract 8GB iPhone 4, and $649 for a 16B iPhone 4S.

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'Hunger Games' Claims Best Fight At MTV Movie Awards

Katniss and Peeta's battle against the cruel and cunning Cato beats out 'Harry Potter' and more in Sunday night's most violent category.
By Josh Wigler and John Mitchell

Alexander Ludwig and Josh Hutcherson win at the 2012 MTV Movie Awards
Photo: Kevin Winter/ Getty Images

Two killers against one — not exactly the fairest of odds, no, but it certainly sets the stage for one of the coolest fights we've seen on screen all year long.

It's only fitting, then, that "The Hunger Games" took home Best Fight at the 2012 MTV Movie Awards Sunday night (June 3), gifting both Jennifer Lawrence and Josh Hutcherson with their second Golden Popcorn statuettes of the night, and bad boy Alexander Ludwig with his first.

The award was presented by "Prometheus" co-stars Charlize Theron and Michael Fassbender, who thought his Irish heritage and famous and much-discussed manliness meant he could handle the duties himself.

"I was thinking since I'm Irish, I would just handle this one," Fassbender rationalized. "Yeah, you know, fighting Irish and all that. And considering you're a girl and all that."

Unfortunately for Fassbender, Theron wasn't having it, and decided to show him exactly how tough even the most glamorous girl can be. The poor guy didn't get past "And the nominees are" before she'd knocked him to the floor with just a handful of swift (mock) blows. For his part, Fassbender played the part of the victim well, writhing on the floor in faux pain before working his way back on his feet.

Just as the "Twilight" films have dominated the Best Kiss category over the past several Movie Awards shows, so too is "Hunger Games" poised to own the Best Fight arena in the years to come. After all, these movies are about unwitting contestants battling to the death — every film from "Catching Fire" to the two-part "Mockingjay" will feature scenes of brutal violence, with lead actors Lawrence and Hutcherson often on the front lines of the action.

"Wow, this is really cool," Hutcherson, who also scored the prize for Best Male Performance, told the audience. "I've always loved doing stunt work [and] producers have always hated me for that because they've never want me to do it."

Hutcherson and Ludwig's fellow Best Fight winner, Best Female Performance winner Jennifer Lawrence, was unable to make it to the awards because she is in Prague filming "Serena."

"We were filming 'til like six in the morning that night so it was an amazing experience," Ludwig added before thanking "Hunger Games" fans for all their support.

Of course, you won't see Ludwig in any future "Hunger Games" fights — his character, the cruel and cunning Cato, was the ill-fated loser of the Movie Awards-winning fight. But District 2 supporters, never fear: You'll get to see the man who plays Cato again very soon when he makes an unlikely "Twilight" crossover with Taylor Lautner in next year's "Grown Ups 2." Who knows? Perhaps that mash-up could be eligible for Best Fight in a couple of years!

The 2012 MTV Movie Awards are officially under way! Stick with MTV News for minute-by-minute coverage, and don't forget to go to MovieAwards.MTV.com to cast your vote for Best Movie!

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